10.08 Haemonc
10.08 Haemonc [PDF link]: Blood products – Packed red cells (RCC), Platelets, CMV-ve and irradiated blood, fresh frozen plasma (FFP), cryoprecipitate, Prothrombin complex, Cell saver devices. Blood product transfusion complications: acute haemolytic reaction, non-haemolytic febrile reaction, minor allergic reaction, anaphylactic reaction, transfusion-related acute lung injury (TRALI), transfusion-associated circulatory overload (TACO). Warfarin – Mx of high INR.
Other notes
Warfarin: NICE guidelines
Management of high INR as above (but with more information in guidelines)
List of important drug interactions that may cause increased/decreased effect of warfarin
When to measure INR?
Measure on 3rd/4th day after starting warfarin, then daily or alternate days until INR is within target range (usually between 2-3)
Then twice weekly for next 2 weeks
Then weekly until at least 2 readings within therapeutic range
Then at longer intervals (per local policy / consultant / anticoagulation team)
Therapeutic ranges for different conditions
